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Paris, 3 August 2014

Pharmacology : serotonin receptor structure revealed

The structure of a serotonin receptor has been completely deciphered for the first time using crystallography. This study, published online in Nature on August 3, 2014, opens the way towards the design of new drugs that might be able to control nausea, one of the main adverse effects of chemotherapy and anesthesia. This work was carried out by a team at the Institut de Biologie Structurale (CNRS/CEA/Université Joseph Fourier) and the Physical Chemistry of Polymers and Membranes Laboratory (EPFL, Switzerland), working in collaboration with scientists from the Architecture et Fonction des Macromolécules Biologiques (CNRS/Université Aix-Marseille) and Dynamique Structurale des Macromolécules (CNRS/Institut Pasteur) laboratories, and with the company, Théranyx.

To download the press release : Cp-sérotonine

References:

X-ray structure of the mouse serotonin 5-HT3 receptor. Ghérici Hassaine, Cédric Deluz, Luigino Grasso, Romain Wyss, Menno B. Tol, Ruud Hovius, Alexandra Graff, Henning Stahlberg, Takashi Tomizaki, Aline Desmyter, Christophe Moreau, Xiao-Dan Li, Frédéric Poitevin, Horst Vogel and Hugues Nury. Nature, online on August 3, 2014. DOI : 10.1038/nature13552

Contact information:

CNRS researcher l Hugues Nury l T + 33 4 57 42 85 93 l hugues.nury@ibs.fr
CNRS Press officer l Alexiane Agullo l T +33 1 44 96 43 90 l alexiane.agullo@cnrs-dir.fr


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