Paris, 15 April 2014

Obesity : are lipids hard drugs for the brain ?

Why can we get up for a piece of chocolate, but never because we fancy a carrot? Serge Luquet's team at the "Biologie Fonctionnelle et Adaptative" laboratory (CNRS/Université Paris Diderot) has demonstrated part of the answer: triglycerides, fatty substances from food, may act in our brains directly on the reward circuit, the same circuit that is involved in drug addiction. These results, published on April 15, 2014 in Molecular Psychiatry, show a strong link in mice between fluctuations in triglyceride concentration and brain reward development. Identifying the action of nutritional lipids on motivation and the search for pleasure in dietary intake will help us better understand the causes of some compulsive behaviors and obesity.

To download the press release: Obesite


Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Céline Cansell, Julien Castel, Raphaël G. P. Denis, Claude Rouch, Anne-Sophie Delbes, Sarah Martinez, Denis Mestivier, Brian Finan, Jaime G. Maldonado-Aviles, Merel Rijnsburger, Matthias H. Tschöp, Ralph J. DiLeone, Robert H. Eckel, Susanne E. la Fleur, Christophe Magnan, Thomas S. Hnasko, Serge Luquet. Molecular Psychiatry. April 15, 2014.


CNRS Researcher l Serge Luquet | T +33 (0)1 57 27 77 93 |
CNRS Press officer l T +33 (0)1 44 96 51 51 l


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