Paris, 29 april 2013

Brilliant dye to probe the brain

To obtain very-high-resolution 3D images of the cerebral vascular system, a dye is used that fluoresces in the near infrared and can pass through the skin. The Lem-PHEA chromophore, a new product outclassing the best dyes, has been synthesized by a team from the Laboratoire de Chimie (CNRS / ENS de Lyon / Université Claude Bernard Lyon 1). Conducted in collaboration with researchers from the Institut des Neurosciences (Université Joseph Fourier - Grenoble / CEA / Inserm / CHU) and the Laboratoire Chimie et Interdisciplinarité: Synthèse, Analyse, Modélisation (CNRS / Université de Nantes), this work has been published online in the journal Chemical Science. It opens up significant prospects for better observing the brain and understanding how it works.

To download the press release : Colorant


A water-soluble probe with near infra-red two-photon absorption and polarity-induced fluorescence for cerebral vascular imaging. Julien Massin, Azzam Charaf-Eddin, Florence Appaix, Yann Bretonnière, Denis Jacquemin, Boudewijn van der Sanden, Cyrille Monnereau and Chantal Andraud
Chemical Science, first published on-line on the 22 April 2013.
DOI: 10.1039/C3SC22325F


Researcher l Cyrille Monnereau I T +33 4 72 72 88 61 l
CNRS press officer l Priscilla Dacher I T +33 1 44 96 46 06 / 51 51 l


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