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Paris, 8 february 2013

Cervical cancer : first 3D image of an HPV oncoprotein

For the first time, researchers from the Laboratoire biotechnologie et signalisation cellulaire at the Strasbourg-based Ecole supérieure de biotechnologie (CNRS/Université de Strasbourg) and Institut de génétique et de biologie moléculaire et cellulaire (CNRS/Université de Strasbourg/Inserm) have solved the three-dimensional structure of an important oncoprotein involved in cell proliferation and in the development of the human papilloma virus (HPV). Type 16 (HPV 16), which causes cervical cancer, is the most dangerous of human papilloma viruses. This work, published in Science on 8 February 2013, should make it possible to identify and improve medication to block the protein and prevent it from causing tumors.

To download the press release :  cancer col uterus

References:

Zanier K, Charbonnier S, Ould M'hamed Ould Sidi A, Mc Ewen AG, Ferrarrio MG, Poussin P., Cura V, Brimer N, Ould Babah K, Ansari T, Muller I, Stote RH, Cavarelli J, Vande Pol S, Travé G. Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science, 8 February 2013, Vol. 339 no. 6120 pp. 694-698, DOI: 10.1126/science.1229934.

Contact information:

CNRS Researchers
Gilles Travé l T +33 (06) 52 47 60 52/ +33 (0)3 68 85 47 20 l gilles.trave@unistra.fr
Katia Zanier l T +33 (0)3 68 85 44 06 l zanier@unistra.fr

CNRS Press officer l Laetitia Louis l T +33 (0)1 44 96 51 37 l laetitia.louis@cnrs-dir.fr


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