Paris, April 3, 2008
Hepatitis C is a major public health problem that affects some 130 million people throughout the world. In
HCV uses at least three receptors to enter and infect a hepatocyte. One of these receptors is the CD81 protein, which has the particular characteristic of associating with numerous other proteins. It was by studying these CD81 partner proteins that the researchers identified the EWI-2wint protein, which prevents the recognition of CD81 by the hepatitis C virus and inhibits it at a very early stage in its infective cycle. This protein is present in other types of cells, which could explain why they are not infected by HCV. Discovery of the role of EWI-2wint in hepatocytes has demonstrated the complexity of the mechanisms of entry of HCV into its target cells, and opens the way to new therapeutic approaches.
© CNRS 2008 Sophana Ung (this image is available from the CNRS photo library at: firstname.lastname@example.org)
Figure 1 – The EWI-2wint protein is not present in hepatocytes (liver cells). When it comes into contact with the hepatocyte, the hepatitis C virus can thus bind to the CD81 protein, which will allow it to enter the cell and pursue its infective cycle. In other types of cells in the body, the EWI-2wint protein is present and interacts with CD81, thus preventing the hepatitis C virus from entering these cells.
1) Called EWI-2wint.
The CD81 partner EWI-2wint inhibits hepatitis C virus entry. Vera Rocha-Perugini(1), Claire Montpellier(1), David Delgrange(1), Czeslaw Wychowski(1), François Helle(1), André Pillez(1), Hervé Drobecq(1), François Le Naour(3), Stéphanie Charrin(3), Shoshana Levy(2), Eric Rubinstein(3), Jean Dubuisson(1), Laurence Cocquerel(1).
1) Institut de Biologie de Lille (UMR8161), CNRS, Universités de Lille I et Lille II, Institut Pasteur de Lille.
2) Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, California, USA.
3) Inserm-U602, Institut André-Lwoff, Université Paris XI, Hôpital Paul Brousse, Villejuif.
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